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                          December 8, 2021

       Joe Vazzano
       Chief Financial Officer
       AVENUE THERAPEUTICS, INC.
       1140 Avenue of the Americas, Floor 9
       New York, New York 10036

                                                        Re: AVENUE
THERAPEUTICS, INC.
                                                            Registration
Statement on Form S-3
                                                            Filed December 7,
2021
                                                            File No. 333-261520

       Dear Mr. Vazzano:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Daniel
Crawford at 202-551-7767 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Mark F. McElreath, Esq.