Exhibit 23.1



Consent of Independent Registered Public Accounting Firm


Avenue Therapeutics, Inc.

New York, New York


We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (No. 333-224276) and Form S-8 (No. 333-219972) of Avenue Therapeutics, Inc. of our report dated March 31, 2021, relating to the financial statements which appears in this Annual Report on Form 10-K. Our report contains an explanatory paragraph regarding the Company’s ability to continue as a going concern.





New York, New York

March 31, 2021