Exhibit 16.1



Tel:  212-371-4446

Fax: 212-371-9374


622 Third Ave, Suite 3100

New York, NY 10017




January 25, 2023


Securities and Exchange Commission 

100 F Street N.E. 

Washington, D.C. 20549


We have been furnished with a copy of the response to Item 4.01 of Form 8-K for the event that occurred on January 21, 2023, to be filed by our former client, Avenue Therapeutics, Inc. We agree with the statements made in response to that Item insofar as they relate to our Firm.


Very truly yours,









BDO USA, LLP, a Delaware limited liability partnership, is the U.S. member of BDO International Limited, a UK company limited by guarantee, and forms part of the international BDO network of independent member firms.


BDO is the brand name for the BDO network and for each of the BDO Member Firms.