Exhibit 32.2


Certification of

Interim Chief Financial Officer

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002


I, David J. Horin, Interim Chief Financial Officer of Avenue Therapeutics, Inc. (the “Company”), in compliance with Section 906 of the Sarbanes-Oxley Act of 2002, hereby certify that, to the best of my knowledge, the Company’s Quarterly Report on Form 10-Q for the period ended June 30, 2017 (the “Report”) filed with the Securities and Exchange Commission:


Fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and


The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.


  /s/ David J. Horin 
  David J. Horin
  Interim Chief Financial Officer 
  (Principal Financial and Accounting Officer) 
  August 11, 2017