Exhibit 32.1

 

Certification of Principal Executive Officer Pursuant to 18 U.S.C. Section 1350,

As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

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I, Alexandra MacLean, M.D., Chief Executive Officer of Avenue Therapeutics, Inc. (the “Company”), in compliance with 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, hereby certify that, to the best of my knowledge, the Company’s Annual Report on Form 10-K for the period ended December 31, 2023 (the “Report”) filed with the Securities and Exchange Commission:

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Fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

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The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

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/s/ Alexandra MacLean, M.D.

 

Alexandra MacLean, M.D.

 

Chief Executive Officer

 

(Principal Executive Officer)

 

March 18, 2024

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