Quarterly report pursuant to Section 13 or 15(d)

Note 7 - Stockholders' Equity (Details Textual)

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Note 7 - Stockholders' Equity (Details Textual)
3 Months Ended 6 Months Ended
Jun. 24, 2024
shares
May 10, 2024
USD ($)
$ / shares
May 01, 2024
USD ($)
Apr. 25, 2024
shares
Jan. 05, 2024
USD ($)
$ / shares
shares
Feb. 03, 2023
USD ($)
Jun. 30, 2024
USD ($)
$ / shares
shares
Mar. 31, 2024
$ / shares
shares
Jun. 30, 2023
USD ($)
Jun. 30, 2024
USD ($)
$ / shares
shares
Jun. 30, 2023
USD ($)
shares
May 31, 2024
$ / shares
shares
Apr. 28, 2024
$ / shares
shares
Jan. 31, 2024
$ / shares
shares
Jan. 09, 2024
$ / shares
shares
Dec. 31, 2023
$ / shares
shares
Nov. 30, 2023
$ / shares
shares
Jan. 31, 2023
$ / shares
shares
Jan. 30, 2023
shares
Sep. 22, 2022
Dec. 31, 2021
shares
Sep. 13, 2019
$ / shares
Sep. 13, 2016
shares
Preferred Stock, Shares Authorized (in shares)             2,000,000     2,000,000           2,000,000             2,000,000
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares             $ 0.0001     $ 0.0001           $ 0.0001              
Common Stock, Shares Authorized (in shares)             200,000,000     200,000,000         200,000,000 75,000,000              
Stockholders' Equity Note, Stock Split, Conversion Ratio                   75                          
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares             $ 8.64 $ 29.5   $ 8.64           $ 32.42              
Fair Value Adjustment of Warrants | $             $ (255,000)   $ 150,000 $ (139,000) $ 1,028,000                        
Proceeds from Warrant Exercises | $                   $ 9,421,000 0                        
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares   $ 0.0001         $ 0.0001     $ 0.0001         $ 0.0001 $ 0.0001              
Proceeds from Issuance of Common Stock | $                   $ 295,000 $ 0                        
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period (in shares)               283,000                              
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross (in shares)                   0                          
Invagen Pharmaceuticals Inc [Member]                                              
Contingent Fee, Percentage of Proceeds of Future Financings           7.50%                                  
Contingent Fee, Maximum Allowable Amount | $           $ 4,000,000                                  
Payment of Contingent Fee | $                   $ 600,000                          
Restricted Stock Units (RSUs) [Member]                                              
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount | $             $ 100,000     $ 100,000                          
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)                   1 year 3 months 18 days                          
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period (in shares)                   45                          
Share-Based Payment Arrangement, Option [Member]                                              
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)                   1 year 6 months                          
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount | $             $ 600,000     $ 600,000                          
Two Thousand Fifteen Incentive Plan [Member]                                              
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares) 5,070,223                                       3,556    
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant (in shares)             5,044,701     5,044,701                          
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period (Year) 10 years                                            
Two Thousand Fifteen Incentive Plan [Member] | Maximum [Member] | Incentive Stock Options [Member]                                              
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant (in shares) 5,000,000                                            
Two Thousand Fifteen Incentive Plan [Member] | Maximum [Member] | Share-Based Payment Arrangement, Nonemployee [Member]                                              
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares)                                     70,223        
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant (in shares) 500,000                                            
January 2023 Warrants [Member]                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                                   25,871          
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares         $ 22.545                         $ 116.25          
Fair Value Adjustment of Warrants | $         $ 100,000                                    
November 2023 Warrants [Member]                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                         221,333       194,667            
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares         $ 22.545               $ 22.545       $ 22.545            
New Series A Warrants [Member]                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)         220,538                                    
Warrants and Rights Outstanding, Term (Year)         5 years                                    
Warrants and Rights Issued Classified as Deemed Dividend | $         $ 600,000                                    
New Series B Warrants [Member]                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)         220,538                                    
Warrants and Rights Issued Classified as Deemed Dividend | $         $ 4,300,000                                    
Existing Warrants [Member]                                              
Proceeds from Warrant Exercises | $         $ 4,500,000                                    
October 2022 Warrants [Member]                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                         27,271                    
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares                         $ 116.25                    
Fair Value Adjustment of Warrants | $     $ (100,000)                                        
January 2024 Warrant Inducement [Member]                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                         441,076 25,871                  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares                         $ 22.545 $ 22.545                  
May 2024 Warrant Inducement [Member]                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                       689,680                      
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares                       $ 6.2 6.2                    
Fair Value Adjustment of Warrants | $     200,000                                        
Warrants and Rights Issued Classified as Deemed Dividend | $     4,500,000                                        
Proceeds from Warrant Exercises | $     $ 3,700,000                                        
Warrant Payment, Price Per Share (in dollars per share) | $ / shares                         $ 0.125                    
New Class C Warrants [Member]                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                         689,680                    
New Class D Warrants [Member]                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                         689,680                    
Shelf [Member]                                              
Securities, Remaining Available for Sale, Amount | $             $ 24,600,000     $ 24,600,000                          
ATM Agreement [Member]                                              
Offering Agreement, Maximum Amount | $   $ 3,850,000                                          
Commission Fee, Percent Fee   3.00%                                          
Stock Issued During Period, Shares, New Issues (in shares)             87,683                                
Proceeds from Issuance of Common Stock | $             $ 300,000                                
Common Stock [Member]                                              
Stock Issued During Period, Shares, Reverse Stock Splits (in shares)       86,518     86,518     86,542                          
Stock Issued During Period, Shares, New Issues (in shares)             25,567     53,586 4,997                        
Common Stock [Member] | ATM Agreement [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares)             84,683     84,683                          
Reverse Stock Split [Member]                                              
Stockholders' Equity Note, Stock Split, Conversion Ratio       75     75                                
Preferred Class A [Member]                                              
Preferred Stock, Shares Authorized (in shares)                                             250,000
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares                                           $ 0.0001  
Preferred Stock, Convertible, Conversion Ratio                                       1,125